NCOR2 ELISA Kit for Human(Homo sapiens) | EIAab.comNCOR2 ELISA Kit for Human(Homo sapiens)

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NCOR2 (Gene name),

Nuclear receptor corepressor 2 (Protein name ), NCOR2_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

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Gene name:

NCOR2(CTG26);

Protein name:

Nuclear receptor corepressor 2(N-CoR2);

Alternative:

SMAP270;CTG repeat protein 26;T3 receptor-associating factor(TRAC);Silencing mediator of retinoic acid and thyroid hormone receptor(SMRT);Thyroid-, retinoic-acid-receptor-associated corepressor;

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

Interacts with BCL6, HDAC7 and C1D. Interacts with NR4A2; this interaction increases in the absence of PITX3 (By similarity). Forms a large corepressor complex that contains SIN3A/B and histone deacetylases HDAC1 and HDAC2. This complex associates with the thyroid (TR) and the retinoid acid receptors (RAR) in the absence of ligand, and may stabilize their interaction with TFIIB. Interacts directly with RARA in the absence of ligand; the interaction represses RARA activity. Interacts (isoform SRMT) with HDAC10. Interacts with MINT. Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2. Interacts with CBFA2T3 and ATXN1L. Interacts with RARB; the interaction is weak and does not repress RARB transactivational activity.

Function:

Transcriptional corepressor of NR4A2/NURR1 and acts through histone deacetylases (HDACs) to keep promoters of NR4A2/NURR1 target genes in a repressed deacetylated state (By similarity). Mediates the transcriptional repression activity of some nuclear receptors by promoting chromatin condensation, thus preventing access of the basal transcription. Isoform 1 and isoform 5 have different affinities for different nuclear receptors.

Subcellular Location:

Nucleus

Protein Attributes:

Sequence length:

2525

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2525:

GPHHAWDEEP | KPLLCSQYET | LSDSE

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

MIM:

600848

Pfam:

PF00249

UniGene:

Hs.137510

STRING:

9606.ENSP00000348551

SMR:

Q9Y618

KEGG:

hsa:9612

String:

Q9Y618

Uniprot:

Q9Y618

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ELISA Kit for Human N-CoR2

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E0334h

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96T

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ELISA Kit for Human N-CoR2

Cat.:

E0334m

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96T

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CLIA Kit for Human N-CoR2

Cat.:

U0334m

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Packing:

96T

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CLIA Kit for Human N-CoR2

Cat.:

U0334h

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MSDS:

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Packing:

96T

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Polyclonal Antibody for Human N-CoR2

Cat.:

P0334Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human N-CoR2

Cat.:

P0334Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human N-CoR2

Protein for Human N-CoR2

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

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Recovery

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Linearity

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References

1.

"Identification of TRACs (T3 receptor-associating cofactors), a family of cofactors that associate with, and modulate the activity of, nuclear hormone receptors."
Sande S. , Privalsky M.L.
Mol. Endocrinol.10:813-825(1996) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2)
tissue: Fetal liver.
2.

"Unique forms of human and mouse nuclear receptor corepressor SMRT."
Ordentlich P. , Downes M. , Xie W. , Genin A. , Spinner N.B. , Evans R.M.
Proc. Natl. Acad. Sci. U.S.A.96:2639-2644(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 3);VARIANT THR-1707
tissue: Pituitary.
3.

"SMRTe, a silencing mediator for retinoid and thyroid hormone receptors-extended isoform that is more related to the nuclear receptor corepressor."
Park E.J. , Schroen D.J. , Yang M. , Li H. , Li L. , Chen J.D.
Proc. Natl. Acad. Sci. U.S.A.96:3519-3524(1999) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 4);VARIANT THR-1707
tissue: Cervix adenocarcinoma.
4.

Chen J.D.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 5);VARIANT THR-1707
5.

"The finished DNA sequence of human chromosome 12."
Scherer S.E. , Muzny D.M. , Buhay C.J. , Chen R. , Cree A. , Ding Y. , Dugan-Rocha S. , Gill R. , Gunaratne P. , Harris R.A. , Hawes A.C. , Hernandez J. , Hodgson A.V. , Hume J. , Jackson A. , Khan Z.M. , Kovar-Smith C. , Lewis L.R. , more...
Nature440:346-351(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
6.

Totoki Y. , Toyoda A. , Takeda T. , Sakaki Y. , Tanaka A. , Yokoyama S. , Ohara O. , Nagase T. , Kikuno R.F.
Submitted (2005-03) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-1451;VARIANT GLU-781
tissue: Brain.
7.

"cDNAs with long CAG trinucleotide repeats from human brain."
Margolis R.L. , Abraham M.R. , Gatchell S.B. , Li S.-H. , Kidwai A.S. , Breschel T.S. , Stine O.C. , Callahan C. , McInnis M.G. , Ross C.A.
Hum. Genet.100:114-122(1997) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 428-613
tissue: Brain cortex.
8.

"A transcriptional co-repressor that interacts with nuclear hormone receptors."
Chen J.D. , Evans R.M.
Nature377:454-457(1995) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1023-2525;VARIANT THR-1707
tissue: Cervix adenocarcinoma.
9.

"A core SMRT corepressor complex containing HDAC3 and TBL1, a WD40-repeat protein linked to deafness."
Guenther M.G. , Lane W.S. , Fischle W. , Verdin E. , Lazar M.A. , Shiekhattar R.
Genes Dev.14:1048-1057(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY;COMPONENT OF THE N-COR COMPLEX WITH TBL1X AND HDAC3
10.

"Both corepressor proteins SMRT and N-CoR exist in large protein complexes containing HDAC3."
Li J. , Wang J. , Wang J. , Nawaz Z. , Liu J.M. , Qin J. , Wong J.
EMBO J.19:4342-4350(2000) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COMPONENT OF THE N-COR COMPLEX WITH TBL1X AND HDAC3
11.

"Sharp, an inducible cofactor that integrates nuclear receptor repression and activation."
Shi Y. , Downes M. , Xie W. , Kao H.-Y. , Ordentlich P. , Tsai C.-C. , Hon M. , Evans R.M.
Genes Dev.15:1140-1151(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH MINT
12.

"ETO, a target of t(8;21) in acute leukemia, makes distinct contacts with multiple histone deacetylases and binds mSin3A through its oligomerization domain."
Amann J.M. , Nip J. , Strom D.K. , Lutterbach B. , Harada H. , Lenny N. , Downing J.R. , Meyers S. , Hiebert S.W.
Mol. Cell. Biol.21:6470-6483(2001) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH CBFA2T3
13.

"The N-CoR-HDAC3 nuclear receptor corepressor complex inhibits the JNK pathway through the integral subunit GPS2."
Zhang J. , Kalkum M. , Chait B.T. , Roeder R.G.
Mol. Cell9:611-623(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: COMPONENT OF THE N-COR COMPLEX WITH NCOR1; GPS2; TBL1X; TBL1R AND HDAC3
14.

"Isolation and characterization of a novel class II histone deacetylase, HDAC10."
Fischer D.D. , Cai R. , Bhatia U. , Asselbergs F.A.M. , Song C. , Terry R. , Trogani N. , Widmer R. , Atadja P. , Cohen D.
J. Biol. Chem.277:6656-6666(2002) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH HDAC10
15.

"Retinoic acid receptors beta and gamma do not repress, but instead activate target gene transcription in both the absence and presence of hormone ligand."
Hauksdottir H. , Farboud B. , Privalsky M.L.
Mol. Endocrinol.17:373-385(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARB
16.

"MTA3 and the Mi-2/NuRD complex regulate cell fate during B lymphocyte differentiation."
Fujita N. , Jaye D.L. , Geigerman C. , Akyildiz A. , Mooney M.R. , Boss J.M. , Wade P.A.
Cell119:75-86(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH BCL6
17.

"Boat, an AXH domain protein, suppresses the cytotoxicity of mutant ataxin-1."
Mizutani A. , Wang L. , Rajan H. , Vig P.J.S. , Alaynick W.A. , Thaler J.P. , Tsai C.-C.
EMBO J.24:3339-3351(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH ATXN1L
18.

"Alternative mRNA splicing of SMRT creates functional diversity by generating corepressor isoforms with different affinities for different nuclear receptors."
Goodson M.L. , Jonas B.A. , Privalsky M.L.
J. Biol. Chem.280:7493-7503(2005) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ALTERNATIVE SPLICING (ISOFORM 5)
19.

"Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
Olsen J.V. , Blagoev B. , Gnad F. , Macek B. , Kumar C. , Mortensen P. , Mann M.
Cell127:635-648(2006) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-215; THR-1391; SER-2016 AND SER-2269;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
20.

"Combining protein-based IMAC, peptide-based IMAC, and MudPIT for efficient phosphoproteomic analysis."
Cantin G.T. , Yi W. , Lu B. , Park S.K. , Xu T. , Lee J.-D. , Yates J.R. III
J. Proteome Res.7:1346-1351(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-54;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
21.

"CtBP is an essential corepressor for BCL6 autoregulation."
Mendez L.M. , Polo J.M. , Yu J.J. , Krupski M. , Ding B.B. , Melnick A. , Ye B.H.
Mol. Cell. Biol.28:2175-2186(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS BCL6 COREPRESSOR;INTERACTION WITH BCL6
22.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-152; THR-156; SER-750; SER-753; SER-1259; THR-1391; SER-1487; SER-2065; THR-2073; SER-2234 AND SER-2269;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
23.

"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S. , Helbig A.O. , Slijper M. , Krijgsveld J. , Heck A.J. , Mohammed S.
Anal. Chem.81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
24.

"The basic helix-loop-helix proteins differentiated embryo chondrocyte (DEC) 1 and DEC2 function as corepressors of retinoid X receptors."
Cho Y. , Noshiro M. , Choi M. , Morita K. , Kawamoto T. , Fujimoto K. , Kato Y. , Makishima M.
Mol. Pharmacol.76:1360-1369(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RXRA
25.

"Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
Mayya V. , Lundgren D.H. , Hwang S.-I. , Rezaul K. , Wu L. , Eng J.K. , Rodionov V. , Han D.K.
Sci. Signal.2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-67; SER-149; SER-152; THR-553; SER-554; SER-939; SER-1331; SER-2057; SER-2065; SER-2068; SER-2069; SER-2234 AND SER-2269;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Leukemic T-cell.
26.

"Lysine acetylation targets protein complexes and co-regulates major cellular functions."
Choudhary C. , Kumar C. , Gnad F. , Nielsen M.L. , Rehman M. , Walther T.C. , Olsen J.V. , Mann M.
Science325:834-840(2009) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-878; LYS-959; LYS-1218; LYS-1248; LYS-1970 AND LYS-2037;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
27.

"A unique secondary-structure switch controls constitutive gene repression by retinoic acid receptor."
le Maire A. , Teyssier C. , Erb C. , Grimaldi M. , Alvarez S. , de Lera A.R. , Balaguer P. , Gronemeyer H. , Royer C.A. , Germain P. , Bourguet W.
Nat. Struct. Mol. Biol.17:801-807(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH RARA;MUTAGENESIS OF ARG-2139; VAL-2141 AND THR-2142
28.

"Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
Olsen J.V. , Vermeulen M. , Santamaria A. , Kumar C. , Miller M.L. , Jensen L.J. , Gnad F. , Cox J. , Jensen T.S. , Nigg E.A. , Brunak S. , Mann M.
Sci. Signal.3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-152; SER-554; SER-956; SER-1872; SER-2214; SER-2234 AND SER-2269;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
29.

"Initial characterization of the human central proteome."
Burkard T.R. , Planyavsky M. , Kaupe I. , Breitwieser F.P. , Buerckstuemmer T. , Bennett K.L. , Superti-Furga G. , Colinge J.
BMC Syst. Biol.5:17-17(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
30.

"System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
Rigbolt K.T. , Prokhorova T.A. , Akimov V. , Henningsen J. , Johansen P.T. , Kratchmarova I. , Kassem M. , Mann M. , Olsen J.V. , Blagoev B.
Sci. Signal.4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-149; SER-152; SER-956; SER-1786 AND SER-2269;IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
31.

"A hybrid mechanism of action for BCL6 in B cells defined by formation of functionally distinct complexes at enhancers and promoters."
Hatzi K. , Jiang Y. , Huang C. , Garrett-Bakelman F. , Gearhart M.D. , Giannopoulou E.G. , Zumbo P. , Kirouac K. , Bhaskara S. , Polo J.M. , Kormaksson M. , Mackerell A.D. Jr. , Xue F. , Mason C.E. , Hiebert S.W. , Prive G.G. , Cerchietti L. , Bardwell V.J. , more...
Cell Rep.4:578-588(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION AS BCL6 COREPRESSOR;INTERACTION WITH BCL6 AND HDAC3;IDENTIFICATION IN A COMPLEX WITH BCL6 AND BCOR
32.

"Structural and functional analysis of the DEAF-1 and BS69 MYND domains."
Kateb F. , Perrin H. , Tripsianes K. , Zou P. , Spadaccini R. , Bottomley M. , Franzmann T.M. , Buchner J. , Ansieau S. , Sattler M.
PLoS ONE8:E54715-E54715(2013) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH DEAF1
33.

"Mechanism of SMRT corepressor recruitment by the BCL6 BTB domain."
Ahmad K.F. , Melnick A. , Lax S. , Bouchard D. , Liu J. , Kiang C.L. , Mayer S. , Takahashi S. , Licht J.D. , Prive G.G.
Mol. Cell12:1551-1564(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: X-RAY CRYSTALLOGRAPHY (2.2 ANGSTROMS) OF 1422-1438 IN COMPLEX WITH BL6

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